小细胞肺癌发生阻塞性肺炎相关因素分析

目的通过对小细胞肺癌患者是否发生阻塞性肺炎的相关因素对比分析,了解伴有阻塞性肺炎小细胞肺癌患者临床特点。方法采用回顾性分析方法,收集2003年1月至2013年1月大连医科大学附属第二医院所收治的经组织学或细胞学确诊的小细胞肺癌患者共450例。经核查资料后,进入统计学的伴有阻塞性肺炎组100例,不伴有阻塞性肺炎组112例,均为初治。对以下因素进行分析：性别、年龄、居住环境、吸烟情况、分期、肿瘤位置、病理类型、初始疗效、NSE（神经元特异性烯醇化酶）。计数资料率和构成比的比较采用卡方检验。结果本组研究中伴有阻塞性肺炎组患者100例中,吸烟患者占76%,小细胞未分化癌患者占81%,中心型癌患者占52%,广泛期患者占57%,NSE阳性率为92%,均高于不伴有阻塞性肺炎组患者。不伴有阻塞性肺炎组的小细胞癌患者初始疗效有效率明显高于伴有阻塞性肺炎组患者。两组在性别、年龄、居住环境方面差异无统计学意义。结论伴有阻塞性肺炎组的小细胞肺癌患者NSE阳性率高于不伴有阻塞性肺炎组。吸烟是小细胞肺癌患者发生阻塞性肺炎的高危因素。阻塞性肺炎降低小细胞癌患者化疗初始疗效。

Analysis of small cell lung cancer in obstructive pneumonia related factors

Objective Through the relevant factors on whether small cell lung cancer patients with obstructive pneumonia comparative analysis to understand with obstructive pneumonia in patients with small cell lung cancer clinical features. Methods Retrospective analysis method was used to collect in January 2003 - January 2013 by the Second Affiliated Hospital of Dalian Medical University were confirmed by histology and cytology of 450 patients with small cell lung cancer. After checking data, into the statistics of 100 cases with obstructive pneumonia group, 112 cases without obstructive pneumonia group, were treated first. Analysis of the following factors： gender, age, living environment, smoking status, stage, tumor location, pathological type, initial curative effect, NSE. Count data rate and the proportion of using chi-square test. Results The study of 100 patients with obstructive pneumonia group, 76% of smokers, 81% of small cell undifferentiated carcinoma, 52% of central cancer patients, patients with a wide range of 57% , NSE -positive rate was 92% higher than patients without obstructive pneumonia group. The initial efficacy in patients with small cell carcinoma was not associated with obstructive pneumonia group had significantly higher efficiency of patients with obstructive pneumonia group. Differences between the two groups in gender, age, living environment were not statistically significant. Conclusion NSE -positive rate of small cell lung cancer patients with obstructive pneumonia group blocking group was not associated with pneumonia. Smoking is a risk factor for small cell lung cancer patients with obstructive pneumonia. Obstructive pneumonia reduce small cell cancer patients with chemotherapy initial efficacy.