| 乳酸菌DM9054、DM9057的安全性评价 |
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| 引用本文： | 解傲,袁杰利.乳酸菌DM9054、DM9057的安全性评价[J].中国微生态学杂志,2011,23(9):774-779. |
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| 作者姓名： | 解傲 袁杰利 |
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| 作者单位： | 大连医科大学微生态学教研室,辽宁大连,116004 |
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| 基金项目： | 国家“863”计划，国家“973”计划 |
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| 摘 要： | 目的实验评价的2株乳酸菌DM9054和DM9057均分离于泡菜,分别具有降胆固醇和降血压功能,由于其功能性强,性状优良,故本实验对其安全性进行评价,为应用于食品药品生产提供参考依据。方法通过急性毒性试验、耐药性、机体指标、有害代谢产物的评价试验以及其他安全性评价试验检测两实验菌株的安全性。结果在一次性分别使用DM9054和DM9057大剂量灌胃后,动物体征指标无异常;两菌株对部分抗生素具有抗性,但不携带可转移的耐药质粒;使用实验菌株后,机体指标MDA、GSH和SAA的变化基本正常;菌株代谢不产生胆盐羟化酶、硝基还原酶和氨基脱羧酶,但产生乳酸;无溶血作用,长期使用,不发生易位现象。结论乳酸菌DM9054和DM9057总体上是安全的。
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| 关 键 词： | 乳酸菌 安全性 毒性 耐药性 有害代谢产物 |
Safety assessment of Lactobacillus strains DM9054 and DM9057 |
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| XIE Ao,YUAN Jie-li.Safety assessment of Lactobacillus strains DM9054 and DM9057[J].Chinese Journal of Microecology,2011,23(9):774-779. |
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| Authors: | XIE Ao YUAN Jie-li |
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| Institution: | XIE Ao,YUAN Jie-li(Laboratory of Microecology,Dalian Medical University,Dalian 116044,China) |
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| Abstract: | Objective To assess the safety of LAB DM9054 and DM9057 as well as provide references for application in food and medicine production.Method Tests including acute toxicity,drug resistance,organism indicators,harmful metabolites were performed to assess the safety of the two experimental strains.Result After administration of a large dose of DM9054 and DM9057,there were no adverse influence on the weight,habitus or mental state;both of the two strains had resistance to some of the antibiotics,but did not pos... |
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| Keywords: | LAB Safety Toxicity Drug resistance Harmful metabolites |
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