乌司他汀辅助治疗重症肺炎的临床评价

目的观察乌司他汀对重症肺炎患者的肺保护作用,及对住院时间和住院费用的影响。方法将115例急性重症肺炎患者分为乌司他汀治疗组和对照组。对照组进行常规治疗,治疗组在进行常规治疗基础上加用乌司他汀,对比2组患者的临床疗效,治疗前、治疗后第7天C反应蛋白(CRP)、血气、胸片、体温(T)、呼吸(RR)、心率(HR)、血白细胞(WBC)、氧合指数(PaO2/F iO2)、临床肺部感染评分(CPIS)、APACHE-II评分、住院时间及住院费用等。结果治疗组CRP、T、RR、HR、WBC、PaO2/F iO2、CPIS、APACHE-II改善情况明显优于对照组(P<0.05);2组总有效率分别为89.3%、66.1%,差异有统计学意义(P<0.05);治疗组ICU住院时间少于对照组,住院费用减少,差异有统计学意义(P<0.05)。结论乌司他丁辅助治疗重症肺炎患者,可有效减轻患者病情,改善各项炎症指标及氧合指数,减少ICU住院时间,降低住院费用。

Clinical study of ulinastatin for the treatment of severe pneumonia

Objective To study the lung protection of Ulinastatin(UST) in the patients with severe pneumonia,and influence of time in ICU and expenses led by its application.Method 115 acute severe pneumonia patients were divided into the treatment group and control group.The control group was treated with routine treatment,and the treatment group on the basis of conventional therapy was added Ulinastatin 200 000 U,q8h.The patients clinical conditions,blood gas,oxygenation index(PaO2/FiO2),T,RR,HR,WBC,chest x-xay,CPIS,...