致念珠菌性包皮龟头炎白假丝酵母菌对9种抗真菌药物最低抑菌浓度测定

目的检测引起念珠菌性包皮龟头炎的白假丝酵母菌对9种抗真菌药物MIC,为临床治疗念珠菌性包皮龟头炎提供参考依据。方法常规培养分真菌,并鉴定到种,采用最低抑菌浓度法对白假丝酵母菌进行体外药物敏感试验。结果培养分离的12株菌中,白假丝酵母菌占75.00%,白假丝酵母菌生物变种占16.67%,近平滑假丝酵母菌占8.33%;11株白假丝酵母菌耐药率由高到低依次是氟康唑,伊曲康唑,咪康唑,酮康唑,克霉唑,益康唑,5-氟胞嘧啶啶,两性霉素B,制霉菌素,其中6种药物耐药率大于50%。结论白假丝酵母菌仍是造成念珠菌性包皮龟头炎最常见的致病菌,耐多药现象较为普遍,应根据临床实验室的体外药敏试验结果,指导临床合理用药。

Detection of minimum inhibitory concentration of 9 antifungal drugs to Candida albicans from Candidal balanoposthitis

Objective To detect 9 antifungal drugs′ MICs against Candida albicans isolated from Candidal balanoposthitis,and provide reference to Candidal balanoposthitis treatment.Method The Candida were cultured and identified conventionally.The medical susceptibility test was performed by MIC methods.Result Among 12 strains of Candida,the most common organisms were Candida albicans（75.00 %）,followed by biovar Candida albicans（16.67%） and Candida parapsilosis（8.33%）.The sequence of drug resistance rates from high to low was Fluconazol,Itraconazole,Miconazole,Ketoconazole,Clotrimazole,Econazole,Flucytosine,Amphotericin and Mycostatin,respectively,with the resistance rates to 6 of them greater than fifty percent.Conclusion Candida albicans is the most common cause of Candidal balanoposthitis,and generally multi drug resistant.It is important to use the antifungal drugs according the result of drug sensitivity test.