乳杆菌制剂和(或)达克宁治疗外阴阴道假丝酵母菌病的疗效比较

目的探讨乳杆菌制剂治疗外阴阴道假丝酵母菌病(VVC)的疗效。方法将2006年5月至7月在温州医学院附属二院确诊为VVC的患者分为3组,单纯使用达克宁栓者(A组)40例,联合使用达克宁栓及定君生阴道栓者(B组)40例,单纯使用定君生者40例(C组),进行对照。对3组的临床症状及真菌学检查结果进行分析讨论。结果停药3~5 d时,A、B组患者的疗效差异无显著性(P>0.05),C组患者的疗效明显低于A、B两组(P<0.05);停药30~37 d时,A、C组患者的疗效差异无显著性(P>0.05),B组患者的疗效明显高于A、C两组(P<0.05)。结论在应用阴道用乳杆菌治疗VVC时,应首先应用抗真菌药物,当真菌感染得以控制之后再使用乳杆菌,帮助恢复阴道内菌群环境。

Preliminary study of curative effect of lactobacillus and (or) antifungal drugs in women with vulvovaginal candidiasis

Objective To study the effect of lactobacillus(Ding-Jun-Sheng) and(or) antifungal drugs on vulvovaginal candidiasis(VVC).Methods The patients were treated by antifungal drugs(group A),antifungal drugs combined with lactobacillus(group B) and lactobacillus alone(group C).Results 3~5 d after treatment,no significant difference of the treatment effect was found between group A and B(P>0.05),both of which were better than group C(P<0.05),and 30~37 d after treatment,group B were better than group A and C(P<0.05).Conclusions In the treatment of VVC,the antifungal drugs should be used firstly,and lactobacillus can be used to improve the microorganism environment after the infection is controlled.