5434例女性泌尿生殖道HPV感染情况及HPV亚型分析

目的了解泰顺地区女性易感人群人乳头瘤病毒(HPV)感染率和HPV亚型分型情况。方法收集2017年1月至2017年12月于泰顺县人民医院体检及就诊的女性患者泌尿生殖道标本,共5434例。采用PCR反向点杂交法进行HPV分型检测,并对结果进行分析。结果5434例标本中HPV阳性1895例,HPV阳性1309人次。高危型HPV检出1127例,占59.4%;低危型HPV检出356例,占18.8%。入选患者中单一感染935例,占71.4%;多重感染374例,占28.6%。高危型中检出最多的是HPV52型,共210例,占11.1%;其次是HPV58型137例,占7.2%;HPV16型124例,占6.5%;HPV18型62例,占3.3%。HPV52阳性患者集中于41~50岁,HPV53阳性患者集中于31~40岁,HPV16、HPV18阳性患者集中于20~40岁及>60岁。随着患者年龄的增长各HPV亚型的阳性率也在增长,且各年龄段患者均以高危型HPV感染为主(62.36%)。结论泰顺地区女性患者HPV亚型及患者年龄分布情况与我国南方女性HPV感染情况相符,HPV感染率随患者年龄增加而增高。高危型HPV检测对子宫颈癌等相关疾病的筛查及预防具有较高的应用价值。

HPV infection and HPV subtypes in female urinary tract of 5,434 cases

Objective To analyze the HPV infection rate and HPV subtypes in female urogenital tract in Taishun.Methods 5,434 female urinary tract specimens in Taishun People′s Hospital from January to December,2017 were collected and detected for HPV and the genotypes with by PCR-reverse dot blot,and the results were analyzed.Results Among the 5,434 specimens,1,895 were HPV subtype positive,involving 1,309 patients,among which 1,127 were high-risk subtypes,356 were low-risk subtypes.935 patients were single infection(71.4%),while 374 were multiple infection(28.6%).Among the high-risk subtypes,HPV52 was predominant(210 cases,11.1%),followed by HPV58(137 cases,7.2%),HPV16(124 cases,6.5%)and HPV18(62 cases,3.3%).The HPV52 infection patients concentrated in 41-50 years group,HPV53 infection patients in 31-40 years group,while HPV16 and HPV18 infection patients concentrated in 20-30 years group and>60 years group.The positive rate of each subtype increased with age.High-risk HPV infection accounted for 62.36%in all age groups.Conclusion The subtypes and age distribution of HPV infection in women in this region are similar to those in southern China.The detection of high-risk HPV has a high clinical value for the screening and prevention of cervical cancer and other related diseases.