质子泵抑制剂对慢性肝病患者肠道微生态的影响

目的探究质子泵抑制剂(PPIs)对慢性肝病患者肠道微生态的影响。方法选取郑州市第六人民医院2018年12月至2019年3月诊断及拟行PPIs治疗的慢性肝病患者31名,使用奥美拉唑进行治疗,20 mg/次,2次/d,疗程4周,检测治疗前后肠道菌群的构成。结果治疗前后患者肠道菌群构成差异显著:治疗后患者肠道菌群在Shannon指数(4.61±0.62 vs 5.01±0.83;t=2.889,P=0.005)、Simpson指数(0.89±0.09 vs 0.95±0.11;t=3.159,P=0.002)显著低于治疗前;治疗前患者肠道菌群中Coriobacteriaceae、Eggerthella、Ruminococcus、Anaerotruncus、Dorea、Turicibacter、Paraprevotella的相对丰度显著高于治疗后,治疗后肠道菌群中Veillonellaceae、Campylobacter、Haemophilus、Streptococcus、Streptococcaceae、Lactobacillus、Lactobacillaceae的相对丰度显著高于治疗前(均P<0.05)。结论PPIs可改变慢性肝病患者肠道菌群的构成。

The effect of proton pump inhibitors on intestinal microbiota of patients with chronic liver disease

Objective To explore the effect of proton pump inhibitors(PPIs)on intestinal microbiota of patients with chronic liver disease. Methods Thirty-one patients with chronic liver disease from December 2018 to March 2019 were treated with PPIs in our hospital.Omeprazole was administered at the dose of 20 mg bid for 4 weeks;the intestinal flora was detected before and after treatment. Results There were significant differences in the composition of flora before and after treatment.The Shannon index(4.61±0.62 vs 5.01±0.83;t=2.889,P=0.005)and Simpson index(0.89±0.09 vs 0.95±0.11;t=3.159,P=0.002)after treatment were significantly lower than those before treatment.The relative abundances of Coriobacteriaceae,Eggerthella,Ruminococcus,Anaerotruncus,Dorea,Turicibacter and Paraprevotella before treatment were significantly higher,while those of Veillonellaceae,Campylobacter,Haemophilus,Streptococcus,Streptococcaceae,Lactobacillus and Lactobacillaceae after treatment were significantly higher(all P<0.05). Conclusion PPIs can alter the composition of intestinal flora in patients with chronic liver disease.