Antitumor efficacy of combined gene and radiotherapy in animals |
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| Authors: | O A Bezborodova E R Nemtsova A R Gevorkov A V Boyko J B Venediktova I V Alekseenko M B Kostina G S Monastyrskaya E D Sverdlov E V Khmelevskiy R I Yakubovskaya |
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| Abstract: | Antitumor efficacy of the combined suicide gene therapy and radiotherapy was studied on the model of CT26 murine colon adenocarcinoma. CMV-FCU1-IRES-mGM-CSF-pGL3 construct with PEG-PEI-TAT (FCU1–mGM/5-FC) block copolymer as a vector was used for intratumoral administration. Tumors were irradiated with a single 5 Gy dose. The efficacy was evaluated according to the grade of tumor growth inhibition (T/C) and lifespan of the animals. Pronounced antitumor activity of the combined use of FCU1–mGM/5-FC system with radiotherapy on the background of prolonged lifespan and the synergism of the applied methods was revealed. |
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