A Linkage Map of the Canine Genome |
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| Authors: | Cathryn S Mellersh Amelia A Langston Gregory M Acland Melissa A Fleming Kunal Ray Neil A Wiegand Leigh V Francisco Mark Gibbs Gustavo D Aguirre Elaine A Ostrander |
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| Institution: | aClinical Research Division-M318, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98104;bCenter for Canine Genetics and Reproduction, James A. Baker Institute for Animal Health, Cornell University, Ithaca, New York, 14853 |
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| Abstract: | A genetic linkage map of the canine genome has been developed by typing 150 microsatellite markers using 17 three-generation pedigrees, composed of 163 F2individuals. One hundred and thirty-nine markers were linked to at least one other marker with a lod score ≥ 3.0, identifying 30 linkage groups. The largest chromosome had 9 markers spanning 106.1 cM. The average distance between markers was 14.03 cM, and the map covers an estimated 2073 cM. Eleven markers were informative on the mapping panel, but were unlinked to any other marker. These likely represent single markers located on small, distinct canine chromosomes. This map will be the initial resource for mapping canine traits of interest and serve as a foundation for development of a comprehensive canine genetic map. |
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