Neuropeptide Y Receptor Genes on Human Chromosome 4q31–q32 Map to Conserved Linkage Groups on Mouse Chromosomes 3 and 8 |
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| Authors: | CM Lutz WN Frankel JE Richards DA Thompson |
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| Institution: | aThe Jackson Laboratory, Bar Harbor, Maine, 04609;bDepartment of Ophthalmology, University of Michigan Medical School, Ann Arbor, Michigan, 48105;cDepartment of Epidemiology, University of Michigan Medical School, Ann Arbor, Michigan, 48105;dDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, 48105 |
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| Abstract: | Npy1randNpy2r,the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31–q32. We have now assignedNpy1randNpy2rto conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity. |
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