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Discovery of new chemical leads for prostaglandin D2 receptor antagonists |
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| Authors: | Torisu Kazuhiko Kobayashi Kaoru Iwahashi Maki Egashira Hiromu Nakai Yoshihiko Okada Yutaka Nanbu Fumio Ohuchida Shuichi Nakai Hisao Toda Masaaki |
| Institution: | Minase Research Institute, Ono Pharmaceutical Co., Ltd, Shimamoto, Mishima, Osaka 618-8585, Japan. torisu@ono.co.jp |
| Abstract: | A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented. |
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