Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents |
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| Authors: | Tandon Vishnu K Yadav Dharmendra B Singh Ravindra V Vaish Meenu Chaturvedi Ashok K Shukla Praveen K |
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| Institution: | Department of Chemistry, Lucknow University, Lucknow 226007, India. vishnutandon@yahoo.co.in |
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| Abstract: | A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure-activity relationships of these compounds were also studied. The results suggest that compounds 9-22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells. |
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