Synthesis and antimicrobial activity of imidazole and pyridine appended cholestane-based conjugates |
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Authors: | Hong-Seok Kim Jyoti R Jadhav Sung-Ji Jung Jin-Hwan Kwak |
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Institution: | 1. Department of Applied Chemistry, Kyungpook National University, 80 University Road, Buk-gu, Daegu 702-701, Republic of Korea;2. School of Life Science, Handong Global University, Pohang 791-708, Republic of Korea |
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Abstract: | A series of 3α-amino-5α-cholestane and 3α,7α-diamino-5α-cholestane derivatives containing imidazole and pyridine rings were synthesized by simple and effective reductive amination, and their in vitro activities against a range of Gram-positive and Gram-negative strains were evaluated. Most of the compound exhibited enhanced activity against MRSA pathogen. 3α,7α-Di(pyridylmethyl)amino-5α-cholestane 10 showed the highest potency in these series toward the Gram-positive bacteria, Staphylococcus epidermidis 887E, with the lowest MIC value of 1 μg/mL. |
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Keywords: | Cholestane Imidazole Pyridine Antimicrobial activity |
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