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Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes |
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| Authors: | Jun-Jun Qin Ze-Min Lin Yan-Sheng Xu Ji-Wen Ren Jian-Ping Zuo Wei-Min Zhao |
| Institution: | 1. Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People''s Republic of China;2. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People''s Republic of China;3. Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai 201210, People''s Republic of China;4. Gansu Forestry Technological College, No. 58 Mapaoquan Road, Tianshui, Gansu 741020, People''s Republic of China;5. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People''s Republic of China |
| Abstract: | Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides (1–4), named periplosides W-Y and 3-O-formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides (1–4) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A. |
| Keywords: | Spiroorthoester group Pregnane glycosides Immunosuppression |
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