Synthesis and DNA binding properties of an amidine-linked and phenyl-containing analogue of distamycin A |
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Authors: | Moses Lee Lori A White Jennifer A Nobles Stephen M Forrow John A Hartley |
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Institution: | Moses Lee, *, Lori A. White, Jennifer A. Nobles, Stephen M. Forrow,John A. Hartley |
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Abstract: | The synthesis of a novel amidine-linked analogue 1 of the phenyl-containing congener 2 of distamycin A and its DNA binding properties are described. The amidine group in 1 improves its water solubility while retaining the minor groove and AT sequence binding selectively.A phenyl-containing and amidine-linked analogue 1 of distamycin A has improved water solubility while retaining the minor groove and AT sequence binding selectivity to DNA. |
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