[Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging |
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| Authors: | Brigitte Guérin Véronique Dumulon-Perreault Marie-Claude Tremblay Samia Ait-Mohand Patrick Fournier Céléna Dubuc Simon Authier François Bénard |
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| Institution: | 1. Centre d’imagerie moléculaire de Sherbrooke (CIMS), Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 3001, 12th North Avenue Sherbrooke, Québec, Canada J1H 5N4;2. BC Cancer Agency Research Centre, Department of Molecular Oncology, Vancouver, BC, Canada |
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| Abstract: | We substituted a truncated neuropeptide Y (NPY) analog, Pro30, Tyr32, Leu34]NPY(28-36)NH2 also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y1 receptors (NPY1R). Our data suggest that Lys(DOTA)4]BVD15 (Ki = 63 ± 25 nM vs. Ki = 39 ± 34 nM for BVD15) is a potent NPY analog suitable for radiolabeling with metallo positron emitters for PET imaging of breast cancer. |
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