Synthesis and antituberculosis activity of new fatty acid amides |
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| Authors: | Caroline Da Ros Montes D’Oca Tatiane Coelho Tamara Germani Marinho Carolina Rosa Lopes Hack Rodrigo da Costa Duarte Pedro Almeida da Silva Marcelo Gonçalves Montes D’Oca |
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| Institution: | 1. Laboratório Kolbe de Síntese Orgânica, Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil;2. Laboratório de Micobacteriologia, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil |
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| Abstract: | This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 μg/mL for resistance strains. |
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