C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative |
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| Authors: | Patel Pranav Gore Vivek Powell William S Rokach Joshua |
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| Institution: | a Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA
b Meakins-Christie Laboratories, Department of Medicine, McGill University, 3626 St. Urbain Street, Montreal, Quebec, Canada H2X 2P2 |
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| Abstract: | The total synthesis of C20-trifluoro-6(E),8(Z),11(Z),14(Z) 5-oxo-ETE is reported. This compound was designed as an ω-oxidation-resistant analog of 5-oxo-ETE that would be resistant to metabolism. The trifluoro derivative of 5-oxo-ETE stimulated calcium mobilization in neutrophils and desensitized these cells to subsequent exposure to 5-oxo-ETE. |
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| Keywords: | 5-oxo-ETE C20-trifluoro-5-oxo-ETE Calcium mobilization Neutophils Eosinophils |
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