Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition |
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| Institution: | 1. Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan;2. Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan;1. Nucleic Acid Center, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense M, Denmark;2. Nucleic Acid Center, Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark;1. Department of Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, CZ-16521, Prague, Czech Republic;2. Department of Plant Ecology and Weed Sciences, Grassland Research Station, Research Institute of Crop Production Prague, Rolnická 6, CZ-46011, Liberec, Czech Republic;1. Dr. Reddys Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India;2. Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India;3. Department of Chemistry, Krishna University, Krishna Dist., Andhra Pradesh, India;4. Doctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal;1. Industrial Technology Institute, 363, Bauddhaloka Mawatha, Colombo 7, Sri Lanka;2. University of Colombo, Colombo 3, Sri Lanka;3. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo 3, Sri Lanka;1. School of Science, RMIT University, Victoria, 3083, Australia;2. Fluid Air, Spraying Sytems Co. Pty Ltd, Victoria, 3029, Australia |
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| Abstract: | The synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against Candida parapsilosis and echinocandin resistant-Candida is described. |
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| Keywords: | Antifungal ASP9726 Echinocandin Natural product |
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