The copper (II) ion as a carrier for the antibiotic capreomycin against Mycobacterium tuberculosis |
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| Institution: | 1. Substance Abuse and Mental Health Services Administration;2. Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention;3. Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention;4. National Institute on Drug Abuse, the National Institutes of Health |
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| Abstract: | In recent years, the bacterium responsible for tuberculosis has been increasing its resistance to antibiotics resulting in new multidrug resistant Mycobacterium tuberculosis (MR-TB) and extensively drug-resistant tuberculosis (XDR-TB). In this study we use several analytical techniques including NMR, FT-ICR, TOF-MS, LC–MS and UV/Vis to study the copper–capreomycin complex. The copper (II) cation is used as a carrier for the antibiotic capreomycin. Once this structure was studied using NMR, FT-ICR, and MALDI-TOF-MS, the NIH-NIAID tuberculosis cell line for several Tb strains (including antibiotic resistant strains) were tested against up to seven variations of the copper–capreomycin complex. Different variations of copper improved the efficacy of capreomycin against Tb up to 250 fold against drug resistant strains of Tb. |
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| Keywords: | Antibiotic Drug delivery Capreomycin Mycobacterium tuberculosis Tb NMR FT-ICR Mass spec |
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