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Antitumor activity of phenylene bridged binuclear bis(imino-quinolyl)palladium(II) and platinum(II) complexes |
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| Institution: | 1. Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden;2. Dept. of Molecular Medicine and Surgery, Clinical Pain Research, Karolinska Institutet, SE-171 76 Stockholm, Sweden;3. Dept of Pain Management and Research, Oslo University Hospital, Postboks 4950 Nydalen, 0424 Oslo, Norway;2. Institute of Physics-CSE, Silesian University of Technology, Konarskiego 22B, 44-100 Gliwice, Poland |
| Abstract: | Antitumor effects of a known bis(imino-quinolyl)palladium(II) complex 1 and its newly synthesized platinum(II) analogue 2 were evaluated against human breast (MCF-7) and human colon (HT-29) cancer cell lines. The complexes gave cytotoxicity profiles that were better than the reference drug cisplatin. The highest cytotoxic activities were pronounced in complex 2 across the two examined cancer cell lines. Both compounds represent potential active drugs based on bimetallic complexes. |
| Keywords: | Bis(imino-quinolyl) Palladium(II) Platinum(II) Antitumor Cisplatin |
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