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An enantioselective synthesis of (+)-(S)-[n]-gingerols via the l-proline-catalyzed aldol reaction |
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| Authors: | Shichao Ma Shilei Zhang Wenhu Duan Wei Wang |
| Institution: | 1. Department of Pharmaceutical Sciences, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People’s Republic of China;2. Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China;3. Department of Chemistry and Chemical Biology, University of New Mexico, Albuqueruqe, NM 87131-0001, USA |
| Abstract: | An enantioselective approach to (+)-(S)-n]-gingerols (1a–c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials. |
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