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5-Aminopyrimidin-2-ylnitriles as Cathepsin K inhibitors |
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| Authors: | Andrew D Morley Peter W Kenny Brenda Burton Robert A Heald Philip A MacFaul Julia Mullett Ken Page Soraya S Porres Lyn Rosenbrier Ribeiro Phil Smith Stuart Ward Tina J Wilkinson |
| Institution: | 1. AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK;2. Argenta Discovery, 8-9 Spire Green Centre, Harlow, Essex CM19 5TR, UK |
| Abstract: | A series of pyrimidine nitrile inhibitors of Cathepsin K with reduced glutathione reactivity has been identified and Molecular Core Matching (MoCoM) has been used to quantify the effect of an amino substituent at C5. |
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