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Synthesis and cell growth inhibitory properties of substituted (E)-1-phenylbut-1-en-3-ones |
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| Authors: | Sylvie Ducki John A Hadfield Lucy A Hepworth Nicholas J Lawrence Ching-Ying Liu Alan T McGown |
| Institution: | a Dept. of Chemistry, University of Manchester Institute of Science and Technology, PO Box 88, Manchester, M60 1QD, UK b CRC Department of Drug Development, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK |
| Abstract: | A series of (E)-1-phenylbut-1-en-3-ones, based on the naturally occurring (E)-1-(4′-hydroxyphenyl)but-1-en-3-one IC50 (K562) 60 μM], was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-1-(Pentafluorophenyl)but-1-en-3-one IC50 (K562) 1.8 μM] was found to be over 30-fold more active than 1. |
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