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N-Demethylation of nocathiacin I via photo-oxidation |
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| Authors: | Li Wenying Huang Stella Liu Xiaohong Leet John E Cantone Joseph L Lam Kin S |
| Institution: | aBristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA |
| Abstract: | In order to improve aqueous solubility of nocathiacin I (1), a potent antibacterial agent, N-demethylation of the amino-sugar moiety was sought. Irradiation of 1 in DMF/CH2Cl2 with UV light of 380 nm led to a cyclic product 2, which was hydrolyzed to yield the desired nocathiacin VI (3). Treatment of 1 with shorter UV light caused trans–cis isomerization of a c–c double bond. |
| Keywords: | Antibacterial Nocathiacin Photo reaction Oxidation Demethylation |
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