Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors |
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| Authors: | Burnett Duane A Caplen Mary Ann Browne Margaret E Zhau Hongrong Altmann Scott W Davis Harry R Clader John W |
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| Institution: | Schering-Plough Research Institute, 2015 Galloping Hill Road MS 2800, Kenilworth, NJ 07033-0539, USA. duane.burnett@spcorp.com |
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| Abstract: | Fluorescent analogues of the cholesterol absorption inhibitor (CAI), Sch 58235, have been designed and synthesized as single enantiomers. Biological testing reveals that they are potent CAIs and are suitable tools for the investigation of the azetidinone CAI mechanism of action (MOA). |
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