Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid,KRN7000 |
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| Authors: | Ravinder Raju Bernard F Castillo Stewart K Richardson Meena Thakur Ryan Severins Mitchell Kronenberg Amy R Howell |
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| Institution: | 1. Department of Chemistry, University of Connecticut, Storrs, CT 06269-3060, United States;2. Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, United States |
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| Abstract: | Four 3″- and 4″-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4″-fluoro analog led to the production of significant levels of IL-2. |
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