Metallo-β-lactamase inhibitory activity of phthalic acid derivatives |
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Authors: | Yukiko Hiraiwa Akihiro Morinaka Takayoshi Fukushima Toshiaki Kudo |
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Institution: | Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan |
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Abstract: | 4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure–activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1. |
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