Synthesis of fluorescent C24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin |
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| Authors: | Jakub Novotný Kateřina Pospěchová Alexandr Hrabálek Robert Čáp Kateřina Vávrová |
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| Institution: | 1. Centre for New Antivirals and Antineoplastics, Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic;2. Department of Biological and Medicinal Sciences, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic;3. Clinics of Surgery, University Hospital Hradec Králové, Czech Republic |
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| Abstract: | Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzoc]1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools. |
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