Design, synthesis and characterization of podocarpate derivatives as openers of BK channels |
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| Authors: | Cui Yong-Mei Yasutomi Eriko Otani Yuko Yoshinaga Takashi Ido Katsutoshi Sawada Kohei Ohwada Tomohiko |
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| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | We found that the podocarpic acid structure provides a new scaffold for chemical modulators of large-conductance calcium-activated K(+) channels (BK channels). Structure-activity analysis indicates the importance of both the arrangement (i.e., location and orientation) of the carboxylic acid functionality of ring A and the hydrophobic region of ring C for expression of BK channel-opening activity. |
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