1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes |
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| Authors: | Nagaraju Marepu Sunandamma Yeturu Manojit Pal |
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| Institution: | 1. Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur 522510, Andhra Pradesh, India;2. Dr Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India |
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| Abstract: | The 1,2,3-triazole ring fused with pyridine/pyrimidine was explored as new template for the identification of potential antimicrobial agents. The regioselective synthesis of these pre-designed N-heteroarenes was achieved via exploring the application of Buchwald’s strategy (i.e. C–N bond formation/reduction/diazotization/cyclization sequence) to the N-heteroarene system. Two of them showed promising antibacterial (comparable to streptomycin) and several showed potent antifungal (comparable to mancozeb) activities. |
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| Keywords: | 1 2 3-Triazole Pyridine Buchwald’s strategy Antibacterial Antifungal |
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