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3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction |
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| Authors: | Boy Kenneth M Guernon Jason M Sit Sing-Yuen Xie Kai Hewawasam Piyasena Boissard Christopher G Dworetzky Steven I Natale Joanne Gribkoff Valentin K Lodge Nicholas Starrett John E |
| Institution: | Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. boyk@bms.com |
| Abstract: | A series of Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinone core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavernosum tissue strips confirms the potential to effect therapy for ED, the effect being maximal for the 3-amino-2-hydroxy thiol side chain. |
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