Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp |
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| Authors: | Kim Seong-Hwan Ko Hyeonseok Bang Hea-Son Park Seon-Hui Kim Dong-Gyu Kwon Hak Cheol Kim Sun Yeou Shin Jongheon Oh Dong-Chan |
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| Institution: | Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. |
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| Abstract: | Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP(+) (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells. |
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| Keywords: | Phenylpyridine Neuroprotective activity Dung beetle Copris tripartitus Streptomyces |
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