Design and synthesis of a highly selective EP2-receptor agonist. |
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| Authors: | K Tani A Naganawa A Ishida H Egashira K Sagawa H Harada M Ogawa T Maruyama S Ohuchida H Nakai K Kondo M Toda |
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| Institution: | Minase Research Institute, Ono Pharmaceutical Co., Ltd., Shimamoto, Mishima, 618-8585, Osaka, Japan. k.tani@ono.co.jp |
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| Abstract: | EP2-receptor selective agonist 3 was identified by the structural hybridization of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility. |
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