Unusual intramolecular N→O acyl group migration occurring during conjugation of (−)-DHMEQ with cysteine |
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| Authors: | Ikuko Kozawa Kuniki Kato Toshiaki Teruya Kiyotake Suenaga Kazuo Umezawa |
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| Institution: | aDepartment of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan;bDepartment of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | Previously we found that (−)-DHMEQ, a specific NF-κB inhibitor, covalently bound to a specific cysteine of NF-κB component proteins. In the course of formation of the (−)-DHMEQ and protected cysteine conjugate, we observed an unusual intramolecular N→O acyl group migration. |
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| Keywords: | (− )-DHMEQ Cysteine NF-κ B Bioconjugate Rearrangement |
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