Characteristics of the rat behavior following single and multiple exposures of the hypoglycemic insulin doses] |
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| Authors: | S A Shestakova A P Eliseeva A A Lebedev V V Shabaev T M Makarova V M Klimenko |
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| Institution: | St. Petersburg I. P. Pavlov State Medical University, St. Petersburg, 197022, Leo Tolstoy St., 6/8, Russia. |
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| Abstract: | Rats behaviour in the "open field" changed in 2 hrs after a single episode of hypoglycaemia was abolished with glucose whereas no changes occurred in their stereotyped behaviour and intraspecies interaction. In 24 hrs quantitative parameters of the "open field" behaviour normalised although the behaviour still had an altered structure. At the same time, amphetamine-induced stereotyped behaviour's indices became reduced. These and other findings suggest some deeper behavioural changes in rats during their recovery from repeated hypoglycaemic episodes and absence of synchronisation of the insulin effects. |
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