LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506-5p expression |
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| Authors: | Zhiping Chen Tianyu Zhong Tao Li Jinghua Zhong Yang Tang Zhanyu Liu Baodian Ling Lanfeng Wang |
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| Institution: | 1.Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Jiangxi Province, China;2.Department of Oncology, First Affiliated Hospital of Gannan Medical University, Jiangxi Province, China;3.Department of Traditional Chinese Medicine, First Affiliated Hospital of Gannan Medical University, Jiangxi Province, China;4.Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Jiangxi Province, China |
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| Abstract: | The gastric cancer (GC) patients commonly have a poor prognosis due to its invasiveness and distant metastasis. Growing evidence proved that aberrant long non-coding RNAs (lncRNAs) expression contributes to tumor development and progression. LncRNA SNHG15 has been reported to be involved in many different kinds of cancer, while its role in GC remains unclear. In the present study, we found that SNHG15 was up-regulated in GC tissues and cell lines. Silencing SNHG15 suppressed proliferation migration, invasion and promoted apoptosis of AGS cells. More importantly, microRNA-506-5p (miR-506-5p) was predicted as a direct target of SNHG15 by binding its 3′-UTR and further verified using luciferase reporter assay. Meanwhile, the results of rescue experiments revealed that knockdown of miR-506-5p expression reversed the functional effects of SNHG15 silenced cell proliferation, migration, invasion and apoptosis. In conclusion, our findings revealed that SNHG15 executed oncogenic properties in GC progression through targeting miR-506-5p, which might provide a novel target for the GC treatment. |
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| Keywords: | Apoptosis Gastric cancer LncRNA SNHG15 MicroRNA-506-5p Proliferation |
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