Membrane-mediated alterations of intracellular Na+ and K+ in lytic-virus-infected and retrovirus-transformed cells |
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Authors: | Robert F Garry Emin T Ulug Henry R Bose Jr |
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Institution: | (1) The University of Texas at Austin, 78712-1095 Austin, Texas, U.S.A. |
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Abstract: | Infection of chick-embryo fibroblasts and other cells by certain animal viruses results in alterations in the intracellular concentrations of Na+ and K+. Dramatic alterations in monovalent-cation concentrations of lytic-virus-infected cells may favor the synthesis of viral proteins over cellular proteins. More subtle alterations in retrovirus-transformed cells may result in the expression of many morphological and biochemical changes associated with the transformed phenotype. |
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