Cloning of metallothionein cDNA from neonatal rat liver |
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| Authors: | J F B Mercer P Hudson |
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| Institution: | (1) Birth Defects Research Institute, Royal Children's Hospital, Flemington Road, 3052 Parkville, Victoria, Australia;(2) Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, 3052 Parkville, Victoria, Australia |
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| Abstract: | A metallothionein cDNA clone was isolated from a cDNA bank prepared from neonatal r a t liver poly(A)-containing RNA by a colony screening procedure using 32P]cDNA probes prepared from mRNA of either metal-induced or uninduced rat livers. Nucleotide sequence analysis of this clone showed that it contained the entire 3' untranslated region and 30% of the coding sequence for a rat metallothionein. The sequence is remarkably homologous with the mouse metallothionein-I gene. |
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