High affinity GDP binding sites on brown adipose tissue mitochondria of genetically obese ‘fa/fa’ rats |
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Authors: | R R French S J Holt D A York |
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Institution: | (1) Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Bassett Crescent East, S09 3TU Southampton, UK |
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Abstract: | The number of high affinity 3H]GDP binding sites in brown adipose tissue mitochondria is normal in obese ( f a / f a ) rats in contrast to the reduced number of low affinity GDP binding sites. Adrenalectomy corrected the loss of low affinity binding sites in fa/fa rats but had no effect on the number of high affinity sites in either lean or obese rats. Equilibrium dialysis was used to show the presence of both high and low affinity binding sites on the purified 32 kdalton protein. |
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