基于超声驱动磁性纳米粒子的肿瘤细胞灭杀

磁性纳米粒子肿瘤热疗技术是目前国际上肿瘤研究的热点.本文提出了一种基于超声驱动磁性纳米粒子(UDMNP)运动进行肿瘤细胞灭杀的新技术,实现磁性纳米粒子的肿瘤治疗.系统研究了肝癌肿瘤细胞HepG2的治疗效果,在一定超声频率下,改变超声功率和超声作用时间,UDMNP具有明显灭杀效果.实验结果显示,较小超声功率下,肿瘤细胞损伤较小,随着超声功率增加,UDMNP对肿瘤细胞表现出明显的灭杀作用.同时,随着作用时间增加,同一超声功率驱动下UDMNP对细胞的灭杀效果也明显提高,光学显微镜观察到细胞形态发生明显变化.本文提出的UDMNP肿瘤细胞灭杀方法的显著优势是减少了化学毒性和有害辐射,是一种物理性机械损伤技术,对促进磁性纳米粒子的临床医学应用有重要意义.

Tumor Cell Injury Induced by Magnetic Nanoparticles Driven by Ultrasound

Magnetic nanoparticles have played an increasingly important role in biomedical applications, especially in tumor hyperthermia. In this paper, we propose a new method using magnetic nanoparticles driven by ultrasound （UDMNP） for tumor treatment. They have high-speed movements to damage tumor ceils. Taking liver tumor cell HepG2 for example, we conclude that UDMNP has the ability to injure tumor cells significantly at a certain ultrasonic frequency with varying ultrasonic power and time. Tumor cells were affected slightly under low ultrasonic power, but they were apparently damaged by magnetic nanoparticles under increasing ultrasonic power. Driven by the same ultrasonic power, magnetic nanoparticles enhanced effects on the tumor cells with increasing ultrasonic time. The tumor cells had apparent morphological changes compared with the control group. The results show that the method in this paper is effective. One of the most promising advantages chemical toxicity and harmful radiation. This method may nanoparticles in the future. in this approach is that it may significantly diminish promote the biomedical applications of magnetic nanoparticles in the future.