| 人呼吸道合胞病毒活疫苗研究进展 |
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| 引用本文： | 何金生,付远辉,洪涛.人呼吸道合胞病毒活疫苗研究进展[J].中国科学:生命科学,2011,41(1):1-12. |
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| 作者姓名： | 何金生 付远辉 洪涛 |
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| 作者单位： | ① 北京交通大学生命科学与生物工程研究院, 北京 100044;
② 中国疾病预防控制中心病毒病预防控制所, 北京 100052 |
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| 基金项目： | 国家自然科学基金(批准号: 30972604)、北京市自然科学基金(批准号: 7092053)、中国博士后科学基金(批准号: 20100470196)和北京交通大学基本科研业务费(批准号: 2009JBM104)资助项目 |
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| 摘 要： | 人呼吸道合胞病毒是引起婴幼儿支气管炎和肺炎的主要原因,也可导致免疫缺陷病人及老年人群显著发病和死亡.人呼吸道合胞病毒疫苗已被世界卫生组织(World Health Organization,WHO)列为全球最优先发展的疫苗之一.经过50多年的研究,尤其是随着重组技术和反向遗传学的出现,对RSV疫苗的研究取得了重要进展,...
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| 关 键 词： | 人呼吸道合胞病毒 减毒活疫苗 病毒载体疫苗 反向遗传学 重组技术 |
| 收稿时间： | 2010-08-10 |
| 修稿时间： | 2010-11-28 |
Live Virus Vaccines Against Human Respiratory Syncytial Virus |
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| HE JinSheng,FU YuanHui & HONG Tao, College of Life Sciences & Bioengineering,Beijing Jiaotong University,Beijing ,China,Institute for Viral Disease Control , Prevention,Chinese Center for Disease Control , Prevention,Beijing.Live Virus Vaccines Against Human Respiratory Syncytial Virus[J].Scientia Sinica Vitae,2011,41(1):1-12. |
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| Authors: | HE JinSheng FU YuanHui & HONG Tao College of Life Sciences & Bioengineering Beijing Jiaotong University Beijing China Institute for Viral Disease Control Prevention Chinese Center for Disease Control Prevention Beijing |
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| Institution: | 1. College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing 100044, China;
2. Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China |
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| Abstract: | Human respiratory syncytial virus（RSV） is the major cause of bronchiolitis and pneumonia in infants and young children worldwide,and it is also a significant cause of morbidity and mortality in immunocompromised patients and the elderly.For these reasons,there is a need to develop vaccine effective against RSV.Currently,sereral vaccine development strategies are being explored including subunit vaccines and live virus vaccines,etc.The live virus vaccines,either live attenuated RSV vaccines or live attenuated virus vectors encoding RSV protective antigens（vectored vaccines）,are the potential candidate vaccines for seronegative infants,and have been paid more attention.Among them,the rA2cp248/404/1030ΔSH virus has shown to be highly attentuated and moderately immunogenic in infants no more than two months of age,absent with enhanced RSV disease during subsequent natural RSV infection in the vaccinees.Therefore,the current status and development of RSV live vurs vaccines are reviewed. |
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| Keywords: | human respiratory syncytial virus live attenuated RSV vaccines vectored vaccines reverse genetics recombination technology |
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