鼠疫耶尔森氏菌的进化研究:从系统发育学到系统发育基因组学

20世纪90年代末起,基因组学在细菌研究中应用越来越广泛,尤其在进化领域,取得了一系列革命性的发现.本文以鼠疫耶尔森氏菌进化研究为例,介绍了从利用基因组中少数特定片段(等位基因)多态性进行分析的传统系统发育学,到基于大量菌株全基因组序列进行系统发育基因组学的研究发展历程,回顾讨论了基因组学技术的进步为鼠疫菌进化研究领域带来的成果.

From Phylogenetics to Phylogenomics: a Brief Review to the Evolutionary Researches of Yersinia pestis

Since 1990s, genomics has been serving a more and more important role in bacterial researches, especially in the evolutionary studies of pathogens. Numerously novel findings in this area are achieved with the accumulation of the flooding genomics data. Here we focused on the history of evolutionary researches of an important human pathogen, Yersinia pestis, which undergoes dramatic changes from the traditional phylogenetics analysis based on polymorphisms of specific alleles in genomes, to the phylogenomics studies involving whole genome-wide variations of large amount of strains.