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Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions
Institution:1. State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China;2. Department of Pharmacy, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen 518001, China;3. State Key Laboratory of Natural Medicines, Department of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China;4. State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China
Abstract:
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  • Keywords:Metabolism  Bile acids  Mitochondrion  Mitofusin 2  Macrophage  Infection  CP: Metabolism  CP: Molecular biology
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