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Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing
Authors:Danielle M Clancy  Graeme P Sullivan  Hannah BT Moran  Conor M Henry  Emer P Reeves  Noel G McElvaney  Ed C Lavelle  Seamus J Martin
Institution:1. Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin 2, Ireland;2. Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland;3. Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
Abstract:
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  • Keywords:IL-1 family  inflammation  IL-33  IL-36  neutrophil  cathepsin G  elastase  cell death  necrosis  microbial killing
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