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Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
Institution:1. Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany;2. Comprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Member of the German Center for Lung Research (DZL), Helmholtz Zentrum München, 85764 Neuherberg, Germany;3. Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia;4. Institute of Computational Biology (ICB), Helmholtz Zentrum München, 85764 Neuherberg, Germany;5. Department of Mathematics, Technische Universität München, 85748 Garching, Germany;6. Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseases and the University of Bonn, 53127 Bonn, Germany;7. Computational Life Sciences, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany;8. University of Technology Sydney, School of Life Sciences, Faculty of Science, Sydney, NSW 2007, Australia;9. Immune Health, Hunter Medical Research Institute, New Lambton and The University of Newcastle, Newcastle, NSW 2305, Australia;10. School of Biomedical Engineering, Faculty of Engineering and IT, University of Technology Sydney, Garvan Institute of Medical Research, and St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia;11. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 AB Groningen, the Netherlands;12. GRIAC Research Institute, University Medical Center Groningen, 9700 RB Groningen, the Netherlands;13. Immunregulation, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany;14. Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, 7250 TAS, Australia;15. Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany;16. Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands;17. Department of Internal Medicine II, Pneumology, University Hospital Bonn, 53127 Bonn, Germany;18. University Clinics for Radiology, University Hospital Bonn, 53127 Bonn, Germany;19. Modular HPC and AI, German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany;20. Institute of Human Genetics, University of Lübeck, 23562 Lübeck, Germany
Abstract:
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