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Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development
Authors:Guang Yang  Changyang Zhou  Ran Wang  Shisheng Huang  Yu Wei  Xianfa Yang  Yajing Liu  Jianan Li  Zongyang Lu  Wenqin Ying  Xiajun Li  Naihe Jing  Xingxu Huang  Hui Yang  Yunbo Qiao
Institution:1. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;2. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China;3. University of Chinese Academy of Sciences, Beijing 100049, China;4. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;5. Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China
Abstract:
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  • Keywords:base editing  H3R17  CARM1  histone methylation  Yap1 signaling  embryo development
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