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The SH2 Domain Interaction Landscape
Authors:Michele Tinti  Lars Kiemer  Stefano Costa  Martin L Miller  Francesca Sacco  Jesper V Olsen  Martina Carducci  Serena Paoluzi  Francesca Langone  Christopher T Workman  Nikolaj Blom  Kazuya Machida  Christopher M Thompson  Mike Schutkowski  Søren Brunak  Matthias Mann  Bruce J Mayer  Luisa Castagnoli  Gianni Cesareni
Institution:1. Department of Biology, University of Rome Tor Vergata, I-00133 Rome, Italy;2. Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark;3. Department of Proteomics and Signal Transduction, Max-Planck Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany;4. Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark;5. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Alle 6, DK-2970 Hørsholm, Denmark;6. Department of Genetics and Developmental Biology, Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA;7. JPT Peptide Technologies GmBH, Volmerstrasse 5, 12489 Berlin, Germany;8. Institute of Biochemistry and Biotechnology, Department of Enzymology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, 06120 Halle, Germany;9. Istituto Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Via Ardeatina, 306, 00179 Rome, Italy
Abstract:
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  • Highlights? The recognition specificity of 70 SH2 domains is probed ? Recognition specificity diverges faster than sequence ? PepspotDB is a database of protein interactions mediated by SH2 domains
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