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Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells
Authors:Gerard Ruiz-Babot  Mariya Balyura  Irene Hadjidemetriou  Sharon J Ajodha  David R Taylor  Lea Ghataore  Norman F Taylor  Undine Schubert  Christian G Ziegler  Helen L Storr  Maralyn R Druce  Evelien F Gevers  William M Drake  Umasuthan Srirangalingam  Gerard S Conway  Peter J King  Louise A Metherell  Stefan R Bornstein  Leonardo Guasti
Institution:1. Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK;2. University Hospital Carl Gustav Carus, Department of Medicine III, Technische Universität Dresden, 01307 Dresden, Germany;3. Department of Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, SE5 9RS London, UK;4. Department of Endocrinology, University College London Hospitals, NW1 2PG London, UK;5. Paul Langerhans Institute Dresden of Helmholtz Centre Munich at University Clinic Carl Gustav Carus of TU Dresden Faculty of Medicine, Technische Universität Dresden, DZD-German Centre for Diabetes Research, 01307 Dresden, Germany;6. Center for Regenerative Therapies, Technische Universität Dresden, 01307 Dresden, Germany;7. Diabetes and Nutritional Sciences Division, King’s College London, WC2R 2LS London, UK
Abstract:
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  • Keywords:steroidogenic cells  adrenal cortex  steroidogenic factor 1  NR5A1  reprogramming  urine-derived stem cells  adrenal insufficiency  congenital adrenal hyperplasia  disease modeling  transplantation
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