Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction |
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Authors: | Guo Bo-hong Cheng Yi Lin Lv-ping Lin De-hui Wu Wei |
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Institution: | Department of Chinese Herbal Medicine, Guangdong, Guangzhou University of Chinese Medicine, Guangzhou, China. |
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Abstract: | In this study, NOH (NOH?=?N-octadecyl-4-(D-galactopyranosyl)oxy]-2,3,5,6-tetrahydroxy hexanamide) was enzymatically synthesized as a targeting molecule and incorporated into liposomes to prepare a liposome surface modified with galactose. Glycyrrhetinic-acid-loaded liposome (GA-LP) and glycyrrhetinic-acid-loaded liposome surface modified with galactose (NOH-GA-LP) were prepared by the ethanol-injection method. NOH-GA-LP was characterized by morphology, particle size, zeta potential, encapsulation efficiency, release in vitro, and stability. The size of spherical particles was in the range of 179-211?nm. Spherical particles exhibit a positive electrical charge (38.7 mV) and possess high encapsulation efficiency (91.3%) and show sustained release (72% over 48 hours) in vitro. This novel approach for the liposome surface modified with galactose by enzymatic synthesis is expected to provide potential application as a drug carrier for active targeted delivery to hepatocytes. |
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